C3 convertase can be formed by the classical C1q- and immunoglobulin-dependent pathway, the alternative factor-B-dependent pathway and the soluble mannose-binding lectin pathway. The spleen clears ...

Ruxoprubart works by binding to Bb and selectively inhibiting the protease activity of the Alternative Pathway C3 convertase, while preserving the Classical Pathway.

TSP-1 directly bound alternative complement pathway proteins, including factor H, factor B, C3, C5, and C8. Surface plasmon resonance analysis revealed high-affinity interactions with C5 (47 nM ...

The figure focuses on complement activation by means of the alternative pathway because it is the one responsible for hemolysis in PNH. The lightning bolt symbolizes the spontaneous hydrolytic ...