Indeed, when the toxin-releasing cells were exposed to acetate, the toxin levels dropped, and the number of toxin-producing cells was reduced. Now the researchers are curious about whether other ...

Among C. perfringens, the team identified a bacterial subpopulation that produces and releases a toxin known as “netB”. However, this only occurs in the absence of acetate, a short-chain fatty ...

C. perfringens produces the epsilon toxin, which opens the blood vessels in the brain, allowing inflammatory cells to access the CNS.

C. perfringens and epsilon toxin may explain many of these mysteries.” Epsilon toxin in mouse models Previous studies were unable to detect toxin-producing C. perfringens strains, despite growing ...

Probe-based bacterial single-cell RNA sequencing predicts toxin regulation. Nature Microbiology, 2023; DOI: 10.1038/s41564-023-01348-4 ...

They found that the C. perfringens cells that were not producing toxins were well-fed with nutrients. On the other hand, toxin-producing C. perfringens cells appear to be lacking those crucial ...

Now that they know that nutrients play a significant role in toxicity, Rosenthal wonders if there are particular factors found in the environment that may be ‘turning on’ toxin production in other ...

C. perfringens is a widespread bacterium found in the intestines of animals and humans, known for causing severe enteric diseases. It produces over 20 toxins, with the β-2 toxin (CPB2) being ...

This study shows that the secreted C. perfringens toxins lecithinase and perfringolysin O activate the NLRP3 inflammasome via distinct mechanisms. Credit: EMBO reports (2023).

Clostridium perfringens infections represent a significant medical challenge, often progressing to life‐threatening sepsis accompanied by rapid intravascular haemolysis. The bacterium produces ...

They found that the C. perfringens cells that were not producing toxins were well-fed with nutrients. On the other hand, toxin-producing C. perfringens cells appear to be lacking those crucial ...