Beta cell dysfunction occurs when the pancreas fails to make or to release enough insulin, and insulin resistance occurs when cells in the body do not respond fully to insulin. Both beta cell ...

Beta cell dysfunction occurs when the pancreas fails to make or to release enough insulin, and insulin resistance occurs when cells in the body do not respond fully to insulin.

In the study, 55 participants without a history of Type 2 diabetes underwent metabolic testing for insulin resistance and beta cell dysfunction in addition to multi-omics profiling, which included ...

In the study, 55 participants without a history of Type 2 diabetes underwent metabolic testing for insulin resistance and beta cell dysfunction in addition to multi-omics profiling, which included ...

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Nature Communications, 2025; 16 (1) DOI: 10.1038/s41467-025-57241-7 ...

While much research has focused on understanding beta-cell dysfunction in diabetic patients, it has become clear that alpha-cells are also affected in diabetes. Lab-based models of human alpha ...

Radka Szotkowská, Jan Gojda, Andrea Plíhalová, Jiří Weichet, Jana Potočková, Jan Havlík, Jan Polák, Michal Anděl, Visceral Fat Accumulation Is Related to Impaired Pancreatic Blood Perfusion and ...

First, here is what is already known about diabetes. Cells, known as beta-cells, in the pancreas produce and store insulin, a hormone that keeps glucose levels in blood under check.

Biomea Fusion, Inc. has presented promising clinical results for icovamenib, a novel therapy aimed at restoring beta-cell function in patients with type 2 diabetes, at the ATTD 2025 Conference ...