HNF1A mutations are found to dysregulate RNA splicing in pancreatic cells, thereby contributing to the onset of diabetes.

Beta cell dysfunction occurs when the pancreas fails to make or to release enough insulin, and insulin resistance occurs when cells in the body do not respond fully to insulin.

Beta cell dysfunction occurs when the pancreas fails to make or to release enough insulin, and insulin resistance occurs when cells in the body do not respond fully to insulin. Both beta cell ...

Scientific breakthroughs in one disease don't always shed light on treating other diseases. But that's been the surprising ...

In the study, 55 participants without a history of Type 2 diabetes underwent metabolic testing for insulin resistance and beta cell dysfunction in addition to multi-omics profiling, which included ...

Biomea Fusion, Inc. has presented promising clinical results for icovamenib, a novel therapy aimed at restoring beta-cell function in patients with type 2 diabetes, at the ATTD 2025 Conference ...

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Nature Communications, 2025; 16 (1) DOI: 10.1038/s41467-025-57241-7 ...

Similarly, proinsulin and proinsulin/C-peptide ratios -- measures of beta-cell stress and dysfunction -- dropped with retatrutide by up to 70.5% and 61.6%, respectively, in the type 2 diabetes ...

While much research has focused on understanding beta-cell dysfunction in diabetic patients, it has become clear that alpha-cells are also affected in diabetes. Lab-based models of human alpha ...