Bayesian Basket Trial Design for a Longitudinal Ordinal Endpoint In basket trials, subjects all receive the same treatment, which targets a specific mutation or biomarker. Bayesian methods are ...

In 2023 the FDA published guidance on rare diseases. The guidance recognises that many rare diseases are serious conditions ...

The Phase I/IIa basket trial is part of Curasight's strategy to be a leader in the field of theranostics within radiopharmaceuticals and diagnostics, combining improved diagnosis with more ...

[2] Basket, Umbrella, and Platform Trials: The Potential for Master Protocol–Based Trials in Inflammatory Bowel Disease. Gastroenterology (2024). Back to "Clinical Pharmacology and Therapeutics" ...

Here we describe the study design for the registrational Phase 2 part of the PYNNACLE study. Methods: The Phase 2 part of PYNNACLE is an ongoing, global, single-arm, open-label, multicenter basket ...

The Phase 1 RESOLUTION basket trial will evaluate the safety and preliminary efficacy of ALLO-329 in patients with systemic lupus erythematosus, including lupus nephritis, idiopathic inflammatory ...

Key Facts Clinical trials move through four structured phases, from safety testing to long-term effects. Adaptive, basket, and umbrella trials are making cancer research faster and more flexible.

IO Biotech Announces Initiation of Phase 2 Trial of IO102-IO103 in Combination With KEYTRUDA® (pembrolizumab) as First-Line Treatment in a Multi-Arm Basket Trial ...