Prior investigations from the researchers led to the discovery of a particular signaling pathway unique to chronic pain. They found a metabolite called BH4 is produced by sensory neurons in cases ...

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The company's three-year investment had characterized the BH4 pathway in vivo in various pain models, developed and tested more than 1,500 potential BH4 inhibitors and produced a vast amount of data.

"The concentrations of BH4 correlated very well with the pain intensity. So, we naturally thought that this was a great pathway to target." To identify drugs that reduce BH4 levels in pain neurons ...

Based on these findings, the team decided to launch their new research by targeting the BH4 pathway. Strike 3: Aptinyx's pain prospect flunks 3rd midphase trial, sending stock to the basement The ...

The following is a summary of “Tryptophan–kynurenine metabolites associate with inflammation and immunologic phenotypes in common variable immunodeficiency,” published in the May 2025 issue of Journal ...

Now, however, a surprising discovery about BH4 will likely rekindle interest in the once-promising pathway and could have profound implications for treating autoimmunity and cancer. In today's ...