Axonal degeneration refers to the progressive disintegration of the long, slender processes of neurons, which compromises neuronal connectivity and ultimately contributes to functional decline.

Unlike most cells in the human body, neurons—the functional cells of our nervous system—cannot typically replace themselves ...

Axonal degeneration is a key early pathogenic driver of amyotrophic lateral sclerosis and other neurodegenerative diseases. Activation of calpain-2 (CAPN2) is thought to be the critical effector ...

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-42570-2 ...

HKUST researchers reveal microglia’s crucial role in preventing axonal degeneration following spinal cord injury Peer-Reviewed Publication Hong Kong University of Science and Technology ...

To investigate the relationship between loss of myelin and axon degeneration, the researchers studied mouse models of rare diseases carrying defects in the major myelin protein of the central ...

The FDA has granted fast-track designation to an investigational antisense oligonucleotide that targets a specific driver of axonal degeneration in those with ALS, according to the manufacturer ...

Sironax Ltd. has discovered (+) hydrolase SARM1 (SAMD2; MyD88-5) inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis, diabetic neuropathy, multiple sclerosis, Parkinson ...

Credit: The University of British Columbia, Okanagan Campus. Johnstone says his study uses the first automated test specifically designed for measuring degeneration of sensory neurons grown in a lab. ...

Nura Bio aims to stop axon degeneration with a brain-penetrating drug that inhibits SARM1. The company’s lead program, NB-4746, recently completed Phase 1 testing in healthy volunteers.