A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel ...

Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

Researchers have found cold-water acclimation affects cellular function, upregulating protective mechanisms that could ...

Mitochondria and mitochondrial autophagy play a vital role in cellular health and failure of these pathways can have a devastating effect on cellular homeostasis.

Exercise initiates autophagy through multiple pathways, including increased energy demands, production of reactive oxygen species, and activation of energy sensing enzymes like AMPK (adenosine ...

A Dundee academic has been awarded a prestigious national prize for his work on neurodegenerative diseases, including ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

The ssRNA viruses have been known to exploit endosomal vesicular trafficking's pathways associated with autophagy signaling. The non-structural proteins are the key players to interfere with these ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...