The research team also tested the approach in mouse models. When gene editing was performed in the mouse retina, autophagy induction led to about a threefold improvement in editing efficiency.

Illustration showing how autophagy induction increases the efficiency of precise gene editing. In normal cells, DNA breaks caused by CRISPR–Cas9 are frequently repaired through non-homologous ...

Illustration showing how autophagy induction increases the efficiency of precise gene editing. In normal cells, DNA breaks caused by CRISPR–Cas9 are frequently repaired through non-homologous ...

Conversely, treatment with rapamycin, an inducer of autophagy, increased LC3B-II levels and enhanced PARK7 secretion, indicating that autophagy induction was essential for PARK7 secretion.

Conversely, treatment with rapamycin, an inducer of autophagy, increased LC3B-II levels and enhanced PARK7 secretion, indicating that autophagy induction was essential for PARK7 secretion. Notably, ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A Korean research team has become the first in the world to significantly ...

How mitochondria drive autophagy Date: February 16, 2025 Source: Institute for Research in Biomedicine (IRB Barcelona) Summary: A new study unravels the relationship between mitofusins ...

Resistance to SOR in pre-clinical models has been attributed to autophagy induction. Autophagy inhibition with HCQ enhanced SOR-induced cell death and apoptosis in early pre-clinic and clinical ...

Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Nature Aging, 2024; DOI: 10.1038/s43587-023-00548-1 ...