There are two main categories of antipsychotics: typical and atypical. Typical antipsychotics have been around longer and are known as first-generation antipsychotics.

The newer atypical antipsychotics, such as clozapine, olanzapine, risperidone, quetiapine, remoxipride and ziprasidone, all bind more loosely than dopamine to the D 2 receptor and have ...

Receptor binding profiles of several of the representative typical and atypical antipsychotic drugs, including those currently used for first-line treatment of schizophrenia, can be seen in Figure 2.

Medically reviewed by Michael MacIntyre, MDSchizophrenia medication falls under two main categories: older, first-generation, or "typical" antipsychotics and newer drugs for schizophrenia known as ...

The Atypical Atypical? By Jonathan Scheff A new class of antipsychotics aims at NMDA receptors ARTICLE EXTRAS The Treatments A Troubled History First-Generation Antipsychotic Drugs The next generation ...

Establishing whether muscarinic receptor antagonist activity mediates the procholinergic effects of atypical antipsychotic drugs in the hippocampus is of high significance, as memory/executive ...

The use of atypical antipsychotic drugs in the elderly has become wider and wider in recent years; in fact, these agents have novel receptor binding profiles, good efficacy with regard to negative ...

Scientists have resolved the structure of the D2 dopamine receptor bound to the antipsychotic drug risperidone as a key step in designing safer, better drugs.

While atypical antipsychotics block the dopamine D2 receptor directly, this oral agent doesn't bind to this receptor, nor 5-HT2A receptors or other neuroreceptors.

Many schizophrenic and depressed patients experience weight gain and type 2 diabetes in their quests for the life-changing benefits of a major class of antipsychotic drugs. Now researchers may ...

An X-ray structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone reveals an extended binding pocket and indicates structural features that could be used to ...

Six weeks of exposure to the antipsychotic drug olanzapine caused weight gain in mice due to increased fat deposits.