Astrocytes provide neuroprotective effects against degeneration of dopaminergic (DA) neurons and play a fundamental role in DA differentiation of neural stem cells. Here we show that light ...

improved upon a differentiation protocol to generate astrocytes from patient-derived induced pluripotent stem (iPS) cells for modeling an astrocyte-associated disease. Their study is published in ...

Expression analysis identified seven subclusters, in agreement with the finding that astrocytes in the brain can be quite heterogeneous. Because the original differentiation protocol mimicked a spinal ...

regulates stem cell differentiation behaviour like a true "conductor". They observed that the level of expression of this gene declines naturally, a short time before astrocyte production begins.

Working on cortical stem cells from rats, the researchers demonstrate that the bHLH transcription factor Ngn1, in addition to inducing neurogenesis, inhibits the differentiation of neural stem cells ...

Specifically, the research team was able to show that the transcription factors NFIA and ATF3 are important in initiating the differentiation of early astrocytes from their astroglial progenitors.

Astrocytes, the most numerous glial cells in the central nervous system, develop from neural progenitors and undergo differentiation and maturation predominantly after birth. They perform various ...

When studying neuron differentiation from stem cells ... differentiated into 10% fewer neurons and about 13% more astrocytes--a type of glial cell--than normal. The researchers then focused ...

By increasing the efficiency of the differentiation of axoCellsTM astrocytes, cortical excitatory neurons, and microglia, researchers can improve how they regulate the quality and consistency of ...