Six patients have successfully undergone the procedure since it was introduced in November 2024. Read more at ...

Aortic dilatation begins in childhood and is progressive. Children born with a bicuspid aortic valve have a larger ascending aorta that increases in size at a higher rate than that of matched ...

A CT or MRI scan is likely to have more precise results, and it is recommended that people with an aortic root measuring between 3.5 and 4.5 cm get screened annually. Exercise is a two-edged sword.

Objectives: Aortic root dilatation is the main cause of morbidity and mortality in Marfan syndrome (MFS), a disorder caused by mutations in the gene encoding fibrillin-1 and consequent dysregulation ...

In Brief Published: 17 September 2013 Vascular disease Aortic root dilatation reduced with losartan use in patients with Marfan syndrome Nature Reviews Cardiology 10, 617 (2013) Cite this article ...

Original Article Published: 01 May 2002 Prevalence of aortic root dilation in the Ehlers-Danlos syndrome Richard J Wenstrup, Richard A Meyer, Jennifer S Lyle, Leah Hoechstetter, Peter S Rose ...

A 6-month intervention with an exercise target of 10,000 steps per day may slow aortic root dilation in pediatric patients with Marfan syndrome, according to study data published in the Journal of ...

Thoracic aortic aneurysm occurs in approximately six to 10 per 100,000 people. In 2019, aortic aneurysms and dissections caused over 9,000 deaths in the United States.

To prevent these events, surgery to replace the aortic root may be performed when dilatation reaches 4.5-5 cm. Slowing aortic dilatation in Marfan syndrome is an important treatment objective.

In January 2020, due to aortic root dilatation in context of MFS with aortic annulus 19.9 mm (z-score +1.84) and sinus of Valsalva 32.2 mm (z-score +3.75), ST junction 21.83 mm (z-score +1.79) and ...

Introduction: Transforming growth factor β (TGFβ) metabolism plays an important role in the pathogenesis of Marfan syndrome (MFS). Accordingly, drug therapy uses TGFβ receptor blockade to slow down ...