LCGC International spoke with Daniel Meston and Dwight Stoll from Gustavus Adolphus College in St. Peter, Minnesota, USA, ...

Antisense oligonucleotide (ASO) technology has accelerated drug discovery in the last few decades with several ASO-based ...

In the August 14 Proceedings of the National Academy of Sciences, Yee Cho and colleagues at the National Institutes of Health, Bethesda, MD, report the use of DNA microarrays to resolve aspects of the ...

Among the DNA repair genes identified ... These neurons were then treated with an antisense oligonucleotide (ASO) that binds to MSH3 mRNA, reducing its expression, and changes in CAG repeat ...

Takeda is sharpening its oncology focus amid an R&D revamp. Sun Pharma will acquire Checkpoint Therapeutics and an ...

The DNA repair protein MSH3 promotes the growth of CAG expansions in neurons. Knocking it down with an antisense oligonucleotide blocked CAG expansion in HD neurons. The ASO also took down MSH3 in the ...

Investigators in the laboratory of Gemma Carvill, Ph.D., assistant professor in the Ken and Ruth Davee Department of Neurology Division of Epilepsy/Clinical Neurophysiology, have discovered novel ...

Scientists use short oligonucleotides as primers for polymerase chain reaction and next-generation sequencing, in DNA microarrays and fluorescence in situ hybridization, and in antisense therapies. (1 ...

As surprisingly high proportions of eukaryotic genomes are transcribed, with numerous noncoding and antisense RNAs being ... from evolutionarily unrelated DNA is noise, so analysis of cells ...