For relapsed/refractory PTCL. ~25-30% ORR; ~10-15% CR rate Pralatrexate Antifolate chemotherapy agent. For relapsed/refractory PTCL. ~29% ORR; ~11-13% CR rate Stem Cell Transplant (ASCT ...

Summary In the past decade, more effective chemotherapy ... with pemetrexed, an antifolate compound that has been shown to increase the cytotoxic effects of platinum-based drugs.

An understanding of which traditional and newer chemotherapy agents can affect ... pentostatin), and the antifolate agent methotrexate are common antitumor chemotherapeutic agents that work ...

However, when exposed to a poor diet or certain drugs, these people can suffer ... gene mutation suffer more severe side effects of antifolate chemotherapy, Ulrich hypothesizes, is because their ...