Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43443-4 ...

The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43240-z ...

The heavy and light chains are folded into the same beta-sheet general structure but show much variation in the smaller details. The most variable sections of the antibody are the antigen binding ...

Structure of Antibodies Antibodies are Y-shaped molecules composed of four polypeptide chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide ...

Light Chain, which draws on decades of experience in immunology and antibody-based therapies gained as Novimmune, is now seeking partners to take forward candidates identified by Light Chain, as ...

Using the sera of SP14, a patient who displayed the IGHV1-69∗01, IGHV1-69∗02, and IGHV1-69∗20 alleles, the researchers generated several heavy and light chains.

Maerivoet, A., et al. (2024) Enhanced stabilisation and reduced fibril forming potential of an amyloidogenic light chain using a variable heavy domain to mimic the homodimer complex. The FEBS ...

On June 12th, 2023 local time, Sanyou Biopharmaceuticals Co., Ltd. officially announced the launch of "Sanyou Super Trillion Common Light Chain Antibody Discovery Platform" (the "platform").

Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting ant ...

Fish IgM structure sheds light on antibody evolution, study finds Peer-Reviewed Publication Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign ...