Recombinant antibodies and therapeutic proteins—like monoclonal antibodies, bispecific antibodies, and Fc fusion proteins—are ...

The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing ...

The company said it plans to develop its new Chai‑2 platform to design, from square one, completely new antibodies for ...

The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43240-z ...

A single amino acid variation in the inherited structure may yield a significant difference in antibody binding and neutralization. R50 is variable among the different versions of IGHV1-69.

Learn how antibody-drug conjugates are advancing therapies for non-cancer conditions, unlocking new possibilities in ...

The method utilises a “structure-to-sequence” computer algorithm that can relate monoclonal antibody (mAb) structure determined by cryo-EM, to the DNA sequence that would produce that structure.

Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Science Immunology, 2022; 7 (73) DOI: 10.1126/sciimmunol.abm3723 ...

News Release 8-Jul-2022 Scientists analyze structure of antibodies that could be key to more effective cancer treatments Peer-Reviewed Publication University of Southampton ...

See, e.g., Amgen Inc. v. Sanofi, 872 F.3d 1367 (Fed. Cir. 2017). If possible, including at least one 3D structure of an antibody of interest has been found to be a good idea. In Abbvie Deutschland v.

Fish IgM structure sheds light on antibody evolution, study finds Peer-Reviewed Publication Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign ...