Recombinant antibodies and therapeutic proteins—like monoclonal antibodies, bispecific antibodies, and Fc fusion proteins—are ...

Structure of Antibodies Antibodies are Y-shaped molecules composed of four polypeptide chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide ...

The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing ...

Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Science Immunology, 2022; 7 (73) DOI: 10.1126/sciimmunol.abm3723 ...

This is the first in a three-part series of animations about therapeutic antibodies, providing viewers with an overview of antibody structure and function. The other two videos, will cover antibody ...

A single amino acid variation in the inherited structure may yield a significant difference in antibody binding and neutralization. R50 is variable among the different versions of IGHV1-69.

The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43240-z ...

Antibodies: function follows form Antibodies are Y-shaped proteins that reach out to their targets with the tips of each arm. If the antibody interacts with a key part of a microbial structure, it can ...

They engineered various isotypes of 3E1 and 9D2 antibodies bearing different heavy chains, which essentially altered the antibodies' structure and the antibody–cell interactions.