they found that when they added an anti-CRISPR protein 6 h afterward, they could reduce CRISPR’s off-target effects (Sci. Adv. 2017, DOI: 10.1126/sciadv.1701620). Bondy-Denomy cofounded a ...

Current anti-CRISPR proteins are not abundant in nature. and have been identified by studying the DNA of the phages that were able to infect bacteria harbouring CRISPR-Cas9.

Certain phages have evolved small inhibitor proteins known as anti-CRISPRs to inactivate bacteria’s use of CRISPR effectors for immune defense. Researchers have used anti-CRISPR (Acrs ...

The anti-CRISPR proteins AcrIIA2 and AcrIIA4 provide a much needed safety gateway for the use of CRISPR-Cas 9 system. The geneediting tool CRISPR which was considered the breakthrough of 2015 ...

CRISPR-Cas9 gene editing is based on a tactic bacteria developed to protect themselves from viruses. Research now shows that the countermeasure viruses came up with — inhibitory proteins referred to ...

Enter the anti-CRISPR protein AcrVIB1, a promising inhibitor whose exact function has remained a mystery—until now. A ...

In a study published in the journal Cell, researchers detailed identifying anti-CRISPR proteins produced by bacterial viruses, coming up with a technique that will benefit CRISPR by making ...

“We also want to understand exactly how the inhibitor proteins block Cas9 ... an inhibitor to prevent CRISPR from cutting that target in the bacterium’s own genome. Indeed, Rauch and colleagues ...

A protein discovered by co-author Joseph Bondy-Denomy, AcrIIA4 is being called an anti-CRISPR. When tested with a gene that causes sickle cell disease, it disabled the CRISPR-Cas9 and reduced ...

The new study published in Cell Host & Microbe suggests that some anti-CRISPR proteins are more widespread in nature than previously anticipated. These anti-CRISPRs can potentially be used to ...

A new study published in Cell Host & Microbe suggests that some anti-CRISPR proteins are more widespread in nature than previously anticipated. These anti-CRISPRs can potentially be used to regulate ...