Complementary discoveries have the potential to enhance treatment options for antibiotic-resistant infections. Researchers at ...

Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, ...

Cas proteins conduct adaptive immunity in prokaryotes ... Bacteria also possess built-in anti-CRISPR systems, that can repair any damage caused by CRISPR-Cas systems. Defense systems that the ...

Thus, both bacterial CRISPR system and phage anti-CRISPR system are part of a ... For example, for the type I-F CRISPR/Cas system, Cas1 and Cas2 proteins first insert a short segment 'spacer ...

This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search. When the CRISPR Cas9 protein is added to ...

We list below recent highlights on the CRISPR-Cas surveillance pathway. Anti-CRISPR protein targeting type VI CRISPR-Cas complex. Cas13 recognizes complementary viral transcripts to trigger ...

Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume ...

Akribion Therapeutics emerges from stealth with €8 million in seed funding to develop a novel cancer RNA-guided approach ...