At 72 hours after the second dose, the researchers noted that the trained alveolar macrophages produced significantly higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10) without ...

Alveolar Macrophages treated with JBT-101 demonstrated reduced levels of key pro-inflammatory cytokines, TNF- alpha and IL-6 Marketwired Thu, Feb 23, 2017, 5:05 AM ...

Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.

From alveolar injury to extracellular matrix accumulation, the complex biology of pulmonary fibrosis is being unraveled ...

Anti-HLA and anti-neutrophil antibodies transferred from the donor to the recipient are thought to bind to and activate blood leukocytes, which then become sequestered in the lungs where they cause ...

That may cause even more inflammation. Antibodies usually bind to pro-inflammatory receptors on alveolar macrophages, spurring downstream inflammatory activity. But higher levels of sialic acid on an ...

AM are considered anti-inflammatory cells with an important role in phagocytosis of particulate matter, dying cells, and cellular debris, maintaining immune homeostasis through the production of ...

Inflammation is a standard part of our bodies' immune system response. But sometimes this response becomes hyperactivated in our lungs, causing inflammation to continue unchecked, which can be ...

Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis Journal: Nature Published: 2024-07-10 DOI: 10.1038/s41586-024-07660-1 Affiliations: 1 Authors: 3 Go to article ...

This work illuminates the essential role of epithelial ATG5 in defending against P. aeruginosa. Atg5 deficiency impairs bacterial clearance and aggravates inflammation via inflammasome activation ...