HNF1A mutations are found to dysregulate RNA splicing in pancreatic cells, thereby contributing to the onset of diabetes.

Alternative Splicing Goes Mainstream In eukaryotic genetics, the one-gene/one-protein concept has, for the most part, breathed its last. Researchers have rallied behind mechanisms such as alternative ...

RNA-targeted CRISPR approaches that can reverse splicing defects without altering the patient’s genome like traditional gene therapies. Reference: Nikom D, Zheng S. Alternative splicing in ...

Their work also builds a basis for understanding alternative polyadenylation--a much ignored cousin of alternative splicing that helps explain how a 30,000-gene genome might produce more than 120,000 ...

Alternative splicing, a complex and prevalent mechanism in the brain and body, allows a single gene to produce a diversity of proteins, and its dysregulation has been implicated in a number of ...

Alternative splicing in human genes is widely viewed as a mechanism for enhancing proteomic diversity, the authors explained. During alternative splicing, different segments of genes are removed ...

Ze Wu, Jiahui Liang, Chengpeng Wang, Liping Ding, Xin Zhao, Xing Cao, Sujuan Xu, Nianjun Teng, Mingfang Yi, Alternative Splicing Provides a Mechanism to Regulate LlHSFA3 Function in Response to Heat ...

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity. The study, published in Genes & Development, identifies UNC-75/CELF ...