These peptides are helical and amphipathic (characterized by polar and non-polar side-chains on the surface of the helix). When this structure integrates in to the bacterial membrane, it can ...

"Alpha amino acids can be substituted at two positions, but ureido units have one site more," says Guichard. This means that hybrid peptide-oligourea drugs offer more options for optimization.

Chemistry professor Samuel H. Gellman and postdoc Tomohisa Sawada of the University of Wisconsin, Madison, demonstrated the approach by making a 12-amino acid peptide from one β-, one γ-, and 10 ...

These results suggested that the helix region 17-25 of VEGF is involved in VEGF receptor activation. The peptide designed to resemble this region shares numerous biological properties of VEGF, thus ...