The nodule produces a hormone, aldosterone, that controls how much salt is in the body. The new discovery is a gene variant in some of these nodules which leads to a vast, but intermittent, over ...

High blood pressure affects more than 1.5 billion people around the world and is a leading cause of heart disease and stroke.

The fluctuating release of aldosterone throughout the day is also an issue for doctors, which at its peak causes salt overload and hypertension.

Researchers discovered a gene mutation that causes a common type of hypertension (high blood pressure) and a treatment for it. This study was published in the journal, 'Nature Genetics.' ...

Baxdrostat is a highly selective, second-generation, nonimidazole aldosterone synthase inhibitor; 100 times less baxdrostat ...

Hypertension affects 1 in 3 adults globally and is the leading modifiable risk factor for cardiovascular disease. Aldosterone dysregulation, often driven by obesity and primary aldosteronism ...

Lorundrostat reduced blood pressure (BP) in people with confirmed uncontrolled and treatment-resistant hypertension, according to a double-blind randomized trial. With background antihypertensive ...

Under-secretion of aldosterone causes Addison's disease (characterised by low blood pressure) whilst over-secretion causes Conn's syndrome, typified also by low levels of potassium.