The second salient finding of the studies presented is that both spironolactone and eplerenone, classical MR antagonists, lowered but did not abolish the GPR30-mediated effects of aldosterone on VSMC.

Although aldosterone (and probably cortisol) excess is involved in the off-target effects of torcetrapib, they may also involve secretion of endogenous oubain from the adrenal glomerulosa.

The effect of saline infusions on the secretion rate of aldosterone, carried out under carefully defined conditions of metabolic balance, may allow a more thorough delineation of the normal from ...

Aldosterone is well known to contribute to the development of hypertension. Circulating aldosterone penetrates the blood–brain barrier at concentrations paralleling those found in plasma. 8, 9 ...

Patients have higher than normal blood pressure which cannot be controlled by multiple drugs. It can cause muscle weakness, ...

Cardioprotective Effects of Selective Aldosterone Blockade in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) - Medscape - Jun 25, 2004.

Effects of Renin, Angiotensin II and Aldosterone on Blood Pressure and Heart Rate Responses to Bisoprolol and Effects of Bisoprolol Treatment on These Parameters On univariate linear regression ...

THE effect of acute extracellular-fluid volume depletion, induced by the administration of diuretics such as ethacrynic acid, causes an abrupt rise in aldosterone secretion in normal subjects. 1 ...

In a recent study posted to the medRxiv * preprint server, researchers conducted an umbrella review and meta-analysis of the renin-angiotensin-aldosterone system (RAAS) inhibitors' impact on ...

The aim of the analysis was to determine whether this effect is mediated by the renin-angiotensin-aldosterone system (RAAS) in hemodialysis. Serum samples from 62 randomized hemodialysis patients with ...