A new nanoparticle drug has shown preclinical promise in both preventing rheumatoid arthritis and reducing painful flare-ups, ...

Immunomodulatory Nanoparticles Enable Combination Therapies To Enhance Disease Prevention and Flare Control in Rheumatoid ...

Treatment of Lower Back Pain Utilizing a Biomimetic Aggrecan Injection (K. Barbee, M. Marcolongo, E. Vresilovic, and B. Schauer) Download Poster - [PDF] Abstract: Degenerative disc disease of the ...

Aggrecan provides the hydrated gel structure, which is important for the load-bearing properties of joints, and also has a key role in chondrocyte and bone morphogenesis. 4 To date, at least 24 ...

A family participates in a clinical trial for aggrecan deficiency, tracing the ACAN gene mutation back through four generations. Credit: M, the mother in this photo.

Tracing the history of aggrecan gene mutations A research team receives the 2019 Human Growth Award for a clinical trial of growth hormone treatment provided to patients with short stature due to ...

Aggrecan, a major component of proteoglycan (PG) having chondroitin sulfate (CS) in cartilaginous tissues, has become increasingly popular as an ingredient in health food. In fact, proteoglycans ...

In 2017, Andrew Dauber, M.D., MMSc., the division chief of endocrinology at Children's National Health System, led an international consortium of researchers in publishing a manuscript describing ...

Aggrecan is a major component of the brain ECM and of at least a subgroup of PNNs, and contains numerous CS chains with a predominant CS-6 representation. 45, 46 In parallel to PNN development ...

Results As observed in rat overused supraspinatus tendon, total GAGs as well as Dermatan and Chondroitin sulfate were increased in human pathological patellar tendon. Correlatively, PGs such as ...