Interestingly, the “DNA strand inversion model” for gyrase activity was proposed in 1979 by Drs. Patrick O. Brown and the late Nicholas R. Cozzarelli, also in a Science paper, well before researchers ...

Interestingly, the "DNA strand inversion model" for gyrase activity was proposed in 1979 by Drs. Patrick O. Brown and the late Nicholas R. Cozzarelli, also in a Science paper, well before ...

Cas9 activity linearized the DNA circles, and the team sequenced the linear fragments, revealing the sequences where the enzyme cut. The team showed that DNA gyrase treatment more than doubled the ...

Lipeng Feng, Julia E. A. Mundy, Clare E. M. Stevenson, Lesley A. Mitchenall, David M. Lawson, Kaixia Mi, Anthony Maxwell, The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase ...

DNA gyrase operates like a tiny molecular machine, carefully twisting and stabilising bacterial DNA. This twisting, known as supercoiling, is similar to winding an elastic band: as it twists, it ...

Macromolecular crowding potently stimulates DNA supercoiling activity of Mycobacterium tuberculosis DNA gyrase. Journal: Journal of Biological Chemistry Published: 2023-12-01 DOI: 10.1016/j.jbc ...

These developments, underpinned by thorough structure–activity relationship studies, underscore the potential of DNA gyrase inhibitors not only as therapeutics against Gram-positive pathogens ...

How Gyrase's Protein Arms Wrap DNA Using state-of-the-art cryo-electron microscopy, the team captured a snapshot of gyrase at work, revealing how it wraps DNA through outstretched protein arms to ...

DNA gyrase operates like a tiny molecular machine, carefully twisting and stabilising bacterial DNA. This twisting, known as supercoiling, is similar to winding an elastic band: as it twists, it ...

The enzyme wraps DNA in a “figure-of-eight” loop, then precisely breaks and passes strands through each other, resealing them afterward. This is a delicate process—if the DNA remained broken ...

Interestingly, the “DNA strand inversion model” for gyrase activity was proposed in 1979 by Drs. Patrick O. Brown and the late Nicholas R. Cozzarelli, also in a Science paper, well before researchers ...