People with high blood pressure that is uncontrolled or poorly treated with most medications may benefit from a new drug that ...

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally ...

However, this contributes to the pathology of the disease by, among other actions, increasing the release of aldosterone. Aldosterone has been shown to cause coronary inflammation, cardiac ...

The UI team led by Geerling and first author Silvia Gasparini, Ph.D., made their discovery by teasing out the actions of aldosterone, a key hormone for controlling sodium levels. Normally ...

adding a thiazide diuretic may help overcome diuretic resistance through a different mechanism of action. In recent years, aldosterone antagonists have been found to improve outcomes in patients ...