The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction.

Conformational changes within myosin lead to its movement relative to an actin filament. Several crystal structures exist for myosin bound to various nucleotides, but none with bound actin ...

In much the same way that each of our bodies depends on bones for mechanical integrity and strength, each cell within our bodies is governed mechanically by a skeleton of composite materials including ...

Indeed, Fujii and Namba used electron cryomicroscopy to acquire images at 5.2 Å resolution to show a previously unobserved conformational change in the myosin molecule when it interacts with actin.

Myosin has a form of molecular 'legs' that 'march' along actin filaments and thereby create movement. In Apicomplexa, myosin interacts with several other proteins, which together form a complex ...

More information: Marine Maupérin et al, A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics, Nature Communications (2025).

After five years of work, a team from National Biosciences Laboratory (LNBio), in the city of Campinas, has defined the three-dimensional structure of what is called the functional, or active, region ...

Muscles contract thanks to the work of a protein called myosin. Using energy from adenosine triphosphate, this molecular motor works with fibrils of the protein actin to drive muscle contraction.

Myosin V, which is also found in pigment cells, is a protein that consists of two heads attached to a long tail, which can bind to the motor’s molecular ‘cargo.’ Myosin travels over long ...

As expected, PP1c was translocated to the cell membrane upon blue light illumination being exposed upon the OptoMYPT expressing cells, and consequently, actin and myosin-mediated contractile force ...

Molecular Physiology With genetic muscle diseases, the actin and myosin no longer work adequately together and the musculature is weakened as a result. It is not known why the proteins interact less ...