The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction.

The actin and myosin complex (actomyosin) generates contraction force of a muscle utilizing the adenosine triphosphate (ATP) hydrolysis reaction. Many attempts have thus been made to explain the ...

At the molecular level, muscle contraction is defined by myosin molecules pulling actin filaments. New electron cryomicroscopy images with unprecedented resolution taken by researchers at Osaka ...

No one can live without a heart pumping blood to the rest of the body. New research from the University of Missouri School of ...

More information: Marine Maupérin et al, A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics, Nature Communications (2025).

Myosin Regulatory Light Chain Phosphorylation Enhances Cardiac ß-Myosin in Vitro Motility Under Load. Archives of Biochemistry and Biophysics, 580 14-21. Schmidt, W.M., Lehman, W., Moore, J.R. (2015).

The ACTN3 gene — also known as the “ speed gene ”— plays an important role in the actin and myosin contraction of muscle fibers. Professional sprinters possess the ACTN3 gene.

We also collaborate with computational cell biologists to model how NMIIA forces exerted on the nanoscale network structure determine microscale membrane curvature and biconcave shapes. Read more ...

To perform these functions, the actin cytoskeleton associates with an array of specialized protein complexes. In wound repair, cytoskeleton remodeling is driven by the accumulation of actin and myosin ...

As expected, PP1c was translocated to the cell membrane upon blue light illumination being exposed upon the OptoMYPT expressing cells, and consequently, actin and myosin-mediated contractile force ...