Acvr2b has been previously predicted as one of the downstream targets of miR-132 (Jiang et al., 2015). Overexpression of Acvr2b has been previously detected in neuron injury and has been speculated to ...

Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function ...

For further details, refer to the publication: Pan Gao et al., Combined rapamycin and mesenchymal stem/stromal cells derived from induced pluripotent stem cells-mediated delivery of ACVR2B-Fc fusion ...

In previous work, the team demonstrated that iPS cell-derived MSCs engineered to produce ACVR2B-Fc—a decoy receptor that binds and neutralizes excess BMP ligands—could reduce HO in FOP model ...

ChIP assay revealed that spermidine repressed H3K56ac in the promoter of ACVR2B and lowered the binding affinity of Smad3 to the promoters of Myf5 and MyoD. Altogether, our results indicate that ...

AcvR2B pathway inhibition improves overall fiber regeneration and ameliorates tissue homeostasis in injured satellite cell-depleted muscles. (A) Cross-sections of TA muscle from CTL (Upper) and ...