Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis Journal: Nature Communications Published: 2024-03-12 DOI: 10.1038/s41467-024-46386-6 ...

The researchers identified a pro-ferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected pro-survival function of its substrate, 7-dehydrocholesterol (7-DHC).

In a groundbreaking study, researchers have identified a dual role in the intricate dance of cell survival and death. The enzyme 7-dehydrocholesterol reductase (DHCR7) is unveiled as a pro ...