In this review, we detail one orphan Mendelian disease—Smith–Lemli–Opitz syndrome (SLOS) resulting from mutations in 7-dehydrocholesterol reductase (DHCR7). These mutations affect a pathway ...

The enzyme 7-dehydrocholesterol reductase (DHCR7) is unveiled as a pro-ferroptotic player, while its substrate, 7-dehydrocholesterol (7-DHC), surprisingly demonstrates a pro-survival function in ...

The researchers identified a pro-ferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected pro-survival function of its substrate, 7-dehydrocholesterol (7-DHC).

The enzyme 7-dehydrocholesterol reductase (DHCR7) is unveiled as a pro-ferroptotic player, while its substrate, 7-dehydrocholesterol (7-DHC), surprisingly demonstrates a pro-survival function in ...

Thus, the 7-dehydrocholesterol reductase enzyme catalyzes the reduction reaction of the C7–C8 double bond in the 7-dehydrocholesterol molecule and synthesizes the final product: cholesterol.

In a groundbreaking study, a team led by Würzburg Professor José Pedro Friedmann Angeli has shown that the cholesterol precursor 7-dehydrocholesterol (7-DHC) plays a crucial role as an ...