Background: Of the available 5-HT 3 -receptor antagonists (RAs), dolasetron, tropisetron and palonosetron include cardiovascular (CV) warnings/precautions in their labelling that should be considered ...

Randomized translational study of 5-HT3 receptor antagonists for evaluation of chemotherapy-induced nausea and vomiting (CINV) related biomarker and prevention of CINV using questionnaires. Authors: ...

During control conditions excitatory inputs to CVNs were blocked by application of NMDA and AMPA/kainate glutamatergic receptor antagonists, whereas the 5-HT3 and purinergic receptor antagonists ...

Palonosetron, a second-generation antagonist of the 5-hydroxytraptamine 3 (5-HT3) receptor, was not inferior to granisetron in preventing nausea and vomiting in the acute phase—ie, within 24 h ...

LUGANO, Switzerland and TOKYO, April 13, 2011 /PRNewswire/ -- Helsinn Group of Switzerland and Taiho Pharmaceutical Co., Ltd., Japanese licensee of Helsinn's second generation 5-HT3 receptor ...

Purpose: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy ...