This enzyme deficiency happens because of a genetic change you inherit. Without enough 21-hydroxylase, the compounds that make cortisol and the hormone aldosterone, build up in your adrenal glands.

Pre-pubertal gynaecomastia has been described in 11β- but not in 21-hydoxylase deficiency. An 8-yr old boy presented with bilateral 5 cm breast buds: P2 G2 Testes 2/2 ml; height 138.5 cm bone age ...

A 21-hydroxylase deficiency is the most common form of CAH and affects around 1 in 10,000 to 1 in 15,000 people annually in the United States and Europe.

Hence, 21-deoxycortisol is a more specific biomarker of 21-hydroxylase deficiency than is 17-hydroxyprogesterone and has been incorporated into some newborn screening protocols. 24 Furthermore ...

Disorders of cortisol biosynthesis can lead to congenital adrenal hyperplasia, the most common form of which is 21-hydroxylase deficiency (21-OHD). This Review details the clinical features and ...

Yes, I do think we need non-glucocorticoid forms of therapy to treat 21-hydroxylase deficiency congenital adrenal hyperplasia.The most common form of congenital adrenal hyperplasia (CAH) is a ...