Background: Angiotensin-converting-enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are effective treatments for diabetic retinopathy, but randomized trials and meta-analyses ...

This screen yielded seven candidate drugs capable of inhibiting the enzyme at low concentrations, with 50% inhibition occurring at less than 60 μM (50% inhibitory concentration, IC50 of <60 μM).

These data support the potential of ZyVersa’s Inflammasome ASC Inhibitor IC 100 as an effective treatment option for patients with obesity and its associated cardiovascular and metabolic ...

Researchers can mitigate overactive LRRK2 using MLi-2 LRRK2 kinase inhibitor, a molecule that attaches to the enzyme and decreases its activity. Pfeffer added that because the genetic mutation is not ...

NEW ORLEANS — A novel “counterintuitive” intervention that reduces glucokinase activity and limits the buildup of metabolites may enhance insulin secretion and ultimately prevent or even ...

Two earlier post hoc analyses of randomized trials comparing RAS inhibitors with placebo, which included a small percentage of patients with advanced chronic kidney disease, suggested that the use ...