17 alpha-hydroxylase deficiency is a rare congenital adrenal hyperplasia resulting from inactivating mutations in the CYP17A1 gene. This enzyme deficiency disrupts steroidogenesis by impairing ...

Background: Abiraterone acetate (Ab) is an oral inhibitor of 17 alpha hydroxylase and C17,20-Lyase, which are important in adrenal androgen synthesis. A phase I study was undertaken to define the ...

Background: Abiraterone acetate (AA) is an inhibitor of CYP 17 (17 α hydroxylase and C17,20-Lyase), a dual enzyme responsible for androgen synthesis. The mechanism of action of abiraterone is similar ...