Scotia is a town in Hampton County, South Carolina, United States. The population was 215 at the 2010 census. Scotia is located in southwestern Hampton County at 32°40′53″N 81°14′50″W / 32.68139°N 81.24722°W. U.S. Route 321 passes through the center of town, leading north 5 miles to Estill and south the same distance to Garnett. South Carolina Highwa…Scotia is a town in Hampton County, South Carolina, United States. The population was 215 at the 2010 census. Scotia is located in southwestern Hampton County at 32°40′53″N 81°14′50″W / 32.68139°N 81.24722°W. U.S. Route 321 passes through the center of town, leading north 5 miles to Estill and south the same distance to Garnett. South Carolina Highway 333 runs east from Scotia 3 miles to Furman. Hampton, the county seat, is 17 miles northeast of Scotia.