LNP Preparation Kit (SM102) - Creative Biolabs
WEBThis product is a kit for preparing Lipid Nanoparticles (LNP) loaded with nucleic acids, proteins, and drugs, consisting of one tube of mixed lipids (ionizable lipids, cholesterol, helper lipids, PEGylated lipids) and one tube of CPBS.
LipidLaunch™️ SM-102 LNP Kit (Loadable) - caymanchem.com
WEBLipidLaunch™ Loadable SM-102 LNPs enable users to encapsulate RNA cargo in reaction volumes as low as 50 µl, offering greater flexibility in the scale of preparation while preserving costly RNA cargo.
Development of a mRNA Lipid Nanoparticle (mRNA-LNP) Cancer …
WEBNov 15, 2022 — We created mRNA LNPs by mixing an ethanol lipid solution made of ionizable lipid (SS-OP, SM-102, or MC3)/ DOPE/Cholesterol/DMG-PEG 2000 with an aqueous solution of mRNA (eGFP or UNC-GRK4-V mRNA) dissolved in a …
Adjuvant lipidoid-substituted lipid nanoparticles augment the ...
WEBJun 26, 2023 — Our results show that partial substitution of ionizable lipidoid with adjuvant lipidoid not only enhanced mRNA delivery, but also endowed LNPs with Toll-like receptor 7/8-agonistic activity, which...
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
WEBAug 10, 2021 — Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA vaccines are now in clinical use against coronavirus disease 2019...
SM-102 LNP Mix - Helix Biotech
WEBSM-102 LNP Mix, 29mM, 2mL (in Ethanol) This kit comes with a detailed protocol and formulation guidelines to help you quickly start creating and optimizing LNPs with SM-102 for your specific application.
Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a ...
WEBJun 28, 2021 — Proprietary cationic lipids─ALC-0315 (Pfizer) and SM-102 (Moderna) ─are used in the COVID-19 vaccine nanoparticles; both lipids are tertiary amines which are protonated (and thus positively charged) at low pH. Their hydrocarbon chains are connected through biodegradable ester groups, enabling safe clearance after mRNA delivery.
A Combinatorial Library of Lipid Nanoparticles ... - Wiley Online …
WEBSM-102 is the ionizable lipid used for developing an mRNA vaccine against COVID-19 and is approved for mRNA delivery in humans. [ 15 , 22 ] We compared the mRNA delivery efficiency of our LNPs (Lipids 16 and 23) with SM-102 LNP via organ expression, immunogenicity, and toxicology studies.
Recent Advances in the Lipid Nanoparticle-Mediated Delivery of …
WEBCompared to the approved SM-102-LNPs, 4N4T-LNPs show higher mRNA translation efficiency against SARS-CoV-2 and its variants, including Delta and Omicron. Overall, this study found that 4N4T-based lipid delivery technology could aid in the development of sophisticated, efficacious mRNA therapeutics for infectious diseases [ 7 ].
Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery …
WEBMay 31, 2022 — DLin-MC3-DMA (MC3), ALC-0315, and SM-102 are the only ionizable cationic lipids currently clinically approved for RNA therapies. ALC-0315 and SM-102 are structurally similar lipids used in SARS-CoV-2 mRNA vaccines, while MC3 is used in siRNA therapy to knock down transthyretin in hepatocytes.