Arginylglycylaspartic acid - Wikipedia
WEBArginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.
Targeting integrin pathways: mechanisms and advances in …
WEBJan 2, 2023 · Several recent reviews have analyzed the details of both biochemical and mechanical integrin regulation, integrin structure, integrin roles in cancer and fibrosis disease, RGD-binding...
RGD-Binding Integrins Revisited: How Recently Discovered
WEBApr 4, 2021 · The present review comprehensively analyzes the state-of-the-art knowledge on the roles of RGD-binding integrin subtypes in cancer and non-cancerous diseases and outlines the latest achievements in the design and development of synthetic ligands and their application in biomedical, translational, and molecular imaging approaches.
RGD-Binding Integrins Revisited: How Recently Discovered …
WEBApr 4, 2021 · In the present review, we summarize the latest discoveries in RGD-binding integrin (patho-) biology as well as progresses made in the design and application schemes of RGD-based integrin ligands for new and promising approaches in integrin-targeted therapy concepts.
RGD peptide in cancer targeting: Benefits, challenges, solutions, …
WEBFeb 1, 2024 · RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing adverse effects on healthy tissues. RGD‐functionalized drug carriers are a viable option for cancer therapy as this focused approach has demonstrated promise in the future.
Structure–Activity Relationships of RGD-Containing Peptides in Integrin …
WEBJan 24, 2023 · The RGD motif is a cell adhesion sequence that binds to integrins, a receptor family for extracellular matrix proteins. We previously reported that the RGDX 1 X 2 sequence, where X 1 X 2 is VF or NY, is required for integrin αvβ5-mediated cell adhesion.
RGD and other recognition sequences for integrins - PubMed
WEBThe RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands.
The role and regulation of integrins in cell migration and invasion
WEB3 days ago · More recently, SHARPIN regulation of integrin activity has also been demonstrated in vivo; in platelets of SHARPIN-deficient mice and using integrin binding RGD probe-based imaging of the mouse ...
De novo design of highly selective miniprotein inhibitors of …
WEBSep 13, 2023 · The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance.
New Perspectives in Cell Adhesion: RGD and Integrins | Science
WEBThe RGD sequences of each of the adhesive proteins are recognized by at least one member of a family of structurally related receptors, integrins, which are heterodimeric proteins with two membrane-spanning subunits.