Different Subsets of T Cells, Memory, Effector Functions, and CAR-T ...
WEBMar 15, 2016 — This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy––a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells.
Understanding subset diversity in T cell memory - PMC
WEBFeb 2, 2018 — Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. This review argues that the conventional subset nomenclature fails to accurately encompass the distribution of functional traits within this diverse population. What is T cell memory?
The who's who of T‐cell differentiation: Human memory T‐cell subsets ...
WEBOct 30, 2013 — This review illustrates the memory T-cell compartment's complexity according to the phenotypic, functional, and persistence properties of discrete memory subsets. We propose a unified model of human memory T-cell differentiation along with a set of canonical markers to be used for their delineation. Subsets …
Human memory T cells: generation, compartmentalization and …
WEBA Diagram shows the tissue distribution and migration patterns of the major human memory T cell subsets, including three major circulating populations —, stem cell memory T cells (T SCM cells), central memory T cells (T CM cells) and effector memory T cells (T EM cells) — and T RM cells in multiple sites, as well as …
Central memory and effector memory T cell subsets: function, …
WEBRecent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance ...
Human memory T cells: generation, compartmentalization and
WEBDec 13, 2013 — CD45RO + CD45RA − T cells comprise diverse memory T cell subsets, including central memory T (T CM) cells, effector memory T (T EM) cells, stem cell memory T (T SCM) cells and tissue-resident...
Understanding Subset Diversity in T Cell Memory - PubMed
WEBFeb 20, 2018 — Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. Here we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regulation, and …
WEBmemory T cells. Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. Here we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regula-
Understanding Subset Diversity in T Cell Memory - Cell Press
WEBMemory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. Jameson and Masopust argue that the conventional subset nomenclature fails to accurately encompass the distribution of functional traits within this diverse population.
Toward a general model of CD4+ T cell subset specification and memory …
WEBMar 14, 2023 — Central memory T (T CM) cells express lymph node homing receptors and recirculate through secondary lymphoid organs. Effector memory (T EM) cells express homing receptors that facilitate recirculation through non-lymphoid tissue.
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