Alpha-v beta-3 - Wikipedia
WEBαVβ3 is a type of integrin that is a receptor for vitronectin. [1] It consists of two components, integrin alpha V and integrin beta 3 (CD 61), and is expressed by platelets. Furthermore, it is a receptor for phagocytosis on macrophages or dendritic cells. [2]
Integrin αvβ3-Targeted Cancer Therapy - PMC - National Center …
WEBIn this article we will review the role of integrin α v β 3 in angiogenesis, present recent progress in the use of integrin α v β 3 antagonists and integrin-targeted delivery systems as potential cancer therapeutics, and discuss future perspectives.
Integrin-αvβ3 as a Therapeutic Target in Glioblastoma: Back to …
WEBMay 13, 2022 · In this review, we first provided an overview of the different roles fulfilled by integrin-αvβ3 in GBM, as well as different therapeutic strategies developed to target integrin-αvβ3. We finally emphasized the theranostic-dedicated αvβ3-targeting agents currently in development.
An αvβ3 integrin checkpoint is critical for efficient T - Nature
WEBDec 22, 2022 · McKenzie and colleagues find that integrin αvβ3 is upregulated by Gata3 and that this is crucial in inducing FAK–mTOR signaling required for TH2 cell differentiation.
Role of thyroid hormone-integrin αvβ3-signal and therapeutic …
WEBApr 8, 2021 · Integrin αvβ3 is a plasma membrane structural protein linked to signal transduction pathways that are critical to cancer cell proliferation and metastasis. Thyroid hormones, T 4 and to a less extend T 3 bind cell surface integrin αvβ3, to stimulate the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway to stimulate cancer cell growth.
The challenges and opportunities of αvβ3-based ... - ScienceDirect
WEBMar 1, 2023 · In integrin-linked cells, αvβ3 initiates the pro-survival pathway by enhancing PI3K-AKT or NF-κB activity, reducing p53 activation and increasing the expression of the pro-survival molecule Bcl-2. Integrin αvβ3 controls tumor cell survival and plays a critical role in tumor growth.
Integrin alpha (v)beta (3)-Targeted Cancer Therapy - PubMed
WEBIn this article we will review the role of integrin alpha (v)beta (3) in angiogenesis, present recent progress in the use of integrin alpha (v)beta (3) antagonists and integrin-targeted delivery systems as potential cancer therapeutics, and discuss future perspectives.
Emerging therapeutic opportunities for integrin inhibitors
WEBSep 17, 2021 · Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2...
αVβ3 integrin regulates macrophage inflammatory responses via …
WEBThe adhesion receptor αVβ3 integrin is thought to be an important receptor that regulates macrophage differentiation and macrophage responses to external signaling, but it has not been previously identified as a contributor to macrophage-related inflammation.
Activation mechanisms of αVβ3 integrin by binding to
WEBIntegrin αVβ3 plays an important role in regulating cellular activities and in human diseases. Although the structure of αVβ3 has been studied by crystallography and electron microscopy, the detailed activation mechanism of integrin αVβ3 induced by fibronectin remains unclear.