Interleukin-6 in Rheumatoid Arthritis - PubMed
WEBJul 23, 2020 — In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
Interleukin-6 in Rheumatoid Arthritis - PMC - National Center for ...
WEBJul 23, 2020 — In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far. Interleukin (IL)-6 is a prototypical cytokine, featuring pleiotropic and redundant functional activity.
High levels of interleukin-6 in patients with rheumatoid arthritis …
WEBOct 20, 2020 — Increased levels of cytokines, including interleukin-6 (IL-6), reflect inflammation and have been shown to be predictive of therapeutic responses, fatigue, pain, and depression in patients with rheumatoid arthritis (RA), but limited data exist on associations between IL-6 levels and health-related quality of life (HRQoL).
Interleukin-6 Receptor Inhibitors for the Treatment of Rheumatoid ...
WEBInhibitors of IL-6 action can target either the IL-6 ligand itself or the IL-6 receptor. Tocilizumab is a humanized monoclonal antibody targeting the IL-6 receptor that was approved by the FDA in 2010 as an intravenous formulation for the treatment of RA; it was later approved as a subcutaneous formulation.
Interleukin 6 and Rheumatoid Arthritis - PMC - National Center …
WEBJan 12, 2014 — In this paper, we present current evidence of the pathological role of IL-6 in the development of RA and the efficacy and safety profile of TCZ for RA and discuss future aspects of IL-6 targeting strategy for RA.
The Role of Interleukin 6 in the Pathophysiology of Rheumatoid ...
WEBInterleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients with RA and the level correlates with the disease activity and joint destruction.
The role and therapeutic targeting of IL-6 in rheumatoid arthritis
WEBRheumatoid arthritis (RA) is an autoimmune chronic disease with joint and systemic inflammation and it has been found that interleukin-6 (IL-6) plays a key role in RA. Indeed, various clinical studies have proved that the first-in-class IL-6 inhibitor, tocilizumab, a humanized anti-IL-6 receptor mon …
Translating IL-6 biology into effective treatments - Nature
WEBApr 23, 2020 — To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling,...
IL-6 Inhibitors for Rheumatoid Arthritis: What to Expect - Everyday …
WEBFeb 22, 2024 — Two IL-6 inhibitors have been approved by the U.S. Food and Drug Administration for RA: tocilizumab (Actemra) and sarilumab (Kevzara). Adding a new drug to your RA treatment plan will...
Pain: A Review of Interleukin-6 and Its Roles in the Pain of …
WEBMar 5, 2021 — Interleukin (IL)-6 is a proinflammatory cytokine that contributes to the pathogenesis of RA. It exerts systemic effects via signaling through soluble forms of the IL-6 receptor (“trans-signaling”).