Interleukin 2 - Wikipedia
WEBInterleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.
Biology and regulation of IL-2: from molecular mechanisms to …
WEBAug 8, 2018 · IL-2 has been shown to induce STAT5-mediated IL-4Rα expression, priming cells for T H 2 differentiation, as well as to induce epigenetic changes at the Il4 locus, promoting T H 2...
Signaling and Function of Interleukin-2 in T Lymphocytes
WEBApr 4, 2018 · IL-2-responsive T cell subsets have extremely diverse characteristics and proinflammatory and anti-inflammatory biological roles. Moreover, IL-2 inhibits the differentiation of Th17 and Tfh cells (b), thus making IL-2 an important regulator of T cell lineage commitment.
IL-2 Secretion by CD4 - American Association of Immunologists
WEBMay 15, 2004 · The secretion of IL-2 is a critical and early landmark in the activation program of CD4 + T cells in vitro, but the lack of sensitive assays has limited its application for studying T cell activation in vivo.
The IL-2 – IL-2 receptor pathway: Key to understanding multiple ...
WEBSep 21, 2021 · Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are the differential induction of autoimmune responses and tolerance.
Biology and regulation of IL-2: from molecular mechanisms to ... - PubMed
WEBIn the more than 40 years since its discovery, a tremendous amount has been learned regarding the mechanisms that regulate the expression of both IL-2 and its cell surface receptor, its mechanisms of signalling and its range of biological actions.
Interleukin-2: Biology, Design and Application - Cell Press
WEBNov 10, 2015 · Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte responses.
Signaling and Function of Interleukin-2 in T Lymphocytes
WEBApr 26, 2018 · IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both pro- and anti-inflammatory T cells is fundamental to determining the molecular details of immune regulation.
Engineering IL-2 for immunotherapy of autoimmunity and cancer
WEBFeb 25, 2022 · These new IL-2 analogues target Treg cells to counteract the dysregulated immune system in the context of autoimmunity and inflammatory disorders or target effector T cells, memory T cells and...
The role of interleukin-2 during homeostasis and activation of the ...
WEBFeb 17, 2012 · Key Points. Under steady-state resting conditions, interleukin-2 (IL-2) is mainly produced by activated CD4 + T cells in secondary lymphoid organs. The secreted IL-2 is then consumed at the...