HLA-matched platelets (Blood Component) - Medscape Drugs …
WEBHLA-matched platelets are indicated for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions.
Platelet transfusion refractoriness: how do I diagnose and …
WEBDec 4, 2020 · Platelets display class I HLA molecules, platelet-specific glycoproteins, and a low level of ABO on their surface membrane. These antibodies can bind to cognate antigens on the surface of transfused platelets and …
Reducing the Need for HLA-Matched Platelet Transfusion
WEBJun 23, 2021 · Our results with this relatively simple regimen, if generalizable, suggest that the need for HLA-matched platelets could be reduced to close to zero if such procedures were universally adopted.
Refractoriness to platelet transfusion - UpToDate
WEBMay 20, 2024 · This topic discusses the causes, evaluation, and management of refractoriness to platelet transfusion, as defined below. Separate topics discuss: General principles of platelet transfusion – (See "Platelet transfusion: Indications, ordering, and associated risks".) Evaluation of thrombocytopenia.
Evidence-Based Minireview: Strategies to manage a severely HLA ...
WEBDec 9, 2022 · A human leukocyte antigen (HLA) antibody screen reveals a calculated panel-reactive antibody (cPRA) of 100%. The blood bank is notified and low-resolution HLA typing is requested. Introduction. Platelet transfusion refractoriness can be a serious problem among patients with hematologic malignancy.
Evaluation and management of platelet transfusion refractoriness
WEBApr 4, 2022 · Among immune causes, the most common is human leukocyte antigen (HLA) class I molecules. PTR caused by anti-HLA antibodies is usually managed by transfusing HLA-matched platelets.
Diagnosis and Management of Platelet Alloimmunization
WEBNov 1, 2013 · HLA alloimmunization is prevented by the transfusion of leuko-reduced red blood cells and platelets. Antibodies to HLA antigens account for the overwhelming majority of cases of immune platelet refractoriness, with antibodies to platelet-specific antigens being much less common.
The HLA System: Genetics, Immunology, Clinical Testing, and …
WEBFeb 2, 2007 · Platelets express platelet-specific antigens and HLA class I antigens. The development of antibodies to these antigens can cause immune destruction of transfused incompatible platelets, resulting in an immune refractoriness to random …
Human Leucocyte Antigen Sensitisation and Its Impact on …
WEBAug 29, 2019 · Patient HLA antibodies can destroy incompatible platelets and may cause refractoriness to platelet transfusion. Identification of a patient's HLA antibody specificities is necessary for issuing compatible platelets to overcome refractoriness.
WEBProvide HLA/HPA compatible donors from an HLA/HPA typed apheresis donor panel. Define HLA/HPA antibody specificity and select antigen compatible apheresis donors. Cross-match random apheresis platelets to select compatible donors. Guidelines for the Management of Refractoriness to Platelet Transfusion.